PLATELET-LIKE BODIES AND 5-HYDROXYTRYPTAMINE IN URINE
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چکیده
منابع مشابه
Blood and urine 5-hydroxytryptophan and 5-hydroxytryptamine levels after administration of two 5-hydroxytryptamine precursors in normal man.
Six healthy male subjects received equimolar amounts of two 5-hydroxytryptamine (5-HT) precursors, 5-hydroxy-L-tryptophan (5-HTP) and gamma-L-glutamyl-5-hydroxy-L-tryptophan (glu-5-HTP), on two occasions in a randomised cross-over study. There were marked increases in urinary 5-HTP and 5-HT excretion after infusion of both compounds. Mean urinary excretion rate of 5-HT, which was < 0.7 nmol min...
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The development of serotonin receptor knockout mice has provided an opportunity to study antidepressant drug effects in animals with targeted genetic deletion of receptors involved in antidepressant responses. In the current study, the effects of two types of antidepressant drugs, the selective serotonin reuptake inhibitors fluoxetine and paroxetine and the selective norepinephrine reuptake inh...
متن کاملCoupling between platelet 5-hydroxytryptamine and potassium transport.
Platelet plasma membrane vesicles accumulate 5-hydroxytryptamine in response to a gradient of NaCl (out > in). Although potassium ion is not required for this process, a K’ concentration gradient (in > out) elevates the steady state level of 5-hydroxytryptamine accumulation 5-fold. Transport is independent of the generation of an electrical potential (interior negative) across the vesicle membr...
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Plasma membrane vesicles isolated from porcine blood platelets take up approximately 8 to 15 pmol of [3H]imipramine per mg of membrane protein. This apparent binding requires Na+ in the external medium and is reversed by 5-hydroxytryptamine and fluoxetine. The apparent KD for imipramine uptake is 23 nM, which agrees well with the KI for competitive inhibition of 5-hydroxytryptamine transport by...
متن کاملAn assessment of platelet aggregation induced by 5-hydroxytryptamine.
A method of expressing platelet aggregation response after incubation relative to the response before incubation has been used in preference to using direct measurements, and some reasons are given for this choice. The effect of pre-incubating human platelets with reserpine has been compared with the effect of pre-incubation with 5-hydroxytryptamine (5HT). Reserpine inhibited 5HT-induced aggreg...
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ژورنال
عنوان ژورنال: The Japanese Journal of Urology
سال: 1980
ISSN: 0021-5287,1884-7110
DOI: 10.5980/jpnjurol1928.71.3_232